Trabecular Hepatocellular Carcinoma, Ulcerotomy - Trabecular Hepatocellular Carcinoma / Ulcerotomy download album
Trabecular Hepatocellular Carcinoma.
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. It is strongly associated with cirrhosis, from both alcohol and viral etiologies . Clinical presentation. The presentation is variable and, in affluent nations, is often found in the setting of screening programs for patients with known risk factors.
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and is the most common cause of death in people with cirrhosis.
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. The cell(s) of origin are believed to be the hepatic stem cells, although this remains the subject of investigation. Tumors progress with local expansion, intrahepatic spread, and distant metastases. The disease processes, which result in malignant transformation, include a variety of pathways, many of which may be modified by external and environmental factors and eventually lead to genetic changes that delay apoptosis and increase cellular proliferation (see the image below). Hepatocellular carcinoma: pathobiology. Efforts have been made to elucidate the genetic pathways that are altered during.
A moderately differentiated HCC is the most easily recognizable form of HCC. This example shows a trabecular growth pattern with dilated sinusoids. This example of a moderately differentiated HCC shows nuclear atypia in the form of enlarged convoluted nuclei (arrowhead) but retain the cytoplasmic quality of normal hepatocytes. This degree of nuclear atypia is not seen in adenomas. A solid growth pattern with large tumor nodules separated by thick fibrous bands (two arrowheads) can be seen in moderately to poorly differentiated HCC. The malignant nature of such tumor is obvious by the very abnormal architecture. This iated HCC shows a macrotrabecular pattern.
Keywords were hepatocellular carcinoma, grade OR grading, and prognosis appearing on the title or abstract. Figure S1. Histological representation of a low-grade hepatocellular carcinoma. Hepatocellular carcinoma with trabecular architecture (three to four cell thickness) and mild cytological atypia. Some acini can be observed, filled with proteinaceous fluid. This tumor is classified as well differentiated according to the WHO criteria, but is better aligned under ES’s grade II tumors. Figure S2. Histological representation of a high-grade hepatocellular carcinoma.
Page views in 2018: 40,642. Moderately differentiated: trabecular pattern with 4+ cells thick; larger tumor cells than well differentiated HCC with more eosinophilic cytoplasm, distinct nucleoli, pseudoglands, bile and tumor giant cells; most common pattern in advanced HCC. Poorly differentiated: large tumor cells with hyperchromatic nuclei in compact growth pattern with rare trabeculae or bile; prominent pleomorphism, may have spindle cell or small cell areas; may not appear to be hepatocellular.
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. HCC is the fourth most common cause of cancer death in the world with 610,000 deaths per year compared with 519,000 deaths per year for breast cancer (the fifth most common cause). In the United States in 2009, there were 22,620 new cases of liver cancer with 18,160 deaths. 12 The histology grading of HCC ranges from well-differentiated to highly anaplastic tumors. This tumor grade has been found to predict survival.